Patient ordered to drink two glasses of water 2 hours before infusion.Tylenol ordered before and after first dose to prevent acute phase reaction.

Caution should be used in patients with aspirin sensitive asthma.

Calcium levels should be closely monitored for hypocalcemia.

Caution should be used if patient is on a loop diuretic.

Renal panel within 2-4 weeks pre-infusion and 10-14 days post ordered.

On calcium/ Vitamin D 1200mg/800IU daily, in divided doses.

The recommended dose is a 5 mg infusion for the treatment of PagetРІР‚в„ўs disease of bone.

In patients with osteoporosis, the current recommended daily intake of calcium is 1200 mg in divided doses and vitamin D 800 IU to 1000 IU daily.Intravenous zoledronic acid is given for the prevention of osteoporosis as 5mg once every 2 years.Intravenous zoledronic acid for treatment of postmenopausal osteoporosis, treatment to increase bone mass in men with osteoporosis, and treatment and prevention of glucocorticoid-induced osteoporosis is 5mg per 100mL once every 12 months.PagetРІР‚в„ўs disease of bone in males and females - Treatment of Paget's disease of bone in men and women.Glucocorticoid induced osteoporosis - treatment and prevention of glucocorticoid-induced osteoporosis.Postmenopausal osteoporosis: Prevention of male Osteoporosis - treatment to increase bone mass in men with osteoporosis.Postmenopausal osteoporosis: Prevention of female Osteoporosis - treatment and prevention of postmenopausal osteoporosis.Bisphosphonates specifically act on bone cells (osteoclasts) to inhibit bone resorption and turnover activity and reduce progressive bone loss and risk for fracture.Р”Р‡inancial Assistance FDA-Approved Indications Bone is a living tissue constantly being remodeled. Unlike other common bisphosphonates that are taken by mouth, Reclast bypasses the stomach because it is an infusion into the bloodstream. ZOLEDRONIC ACID (Reclast) Zoledronic acid is a bisphosphonate prescribed to prevent or treat osteoporosis or Paget's disease. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.Р”В¬opyright 1996-2018 Cerner Multum, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drug information contained herein may be time sensitive. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Every effort has been made to ensure that the information provided by Cerner Multum, Inc.

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